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This is due to failure of adequate amounts of bile to reach the duodenum, either through a specific failure of canalicular secretion or physical obstruction to bile flow at any level

During pregnancy and lactation, the fetus and infant are entirely reliant on maternal iodine intake for thyroid hormone synthesis

Pearce et al., 1997)

16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM